2018年8月19日星期日

Overuse of Multivitamins could be Harmful

Usage of multivitamins either through prescription or on own accord possibly crossed a limit in the past few years. New research published in Journal of American College of Cardiology reveals that health supplements can increase the risk of heart issues.

Dr Anoop Mishra, the chairman of Fortis C-Doc said, “People take it, often on their own, to make up for the lack of nutrients in their daily food. Sometimes, doctors also over-prescribe them.” He further added, “Self-prescription is even more common. People start taking supplements, for example, the multivitamins, simply because they read in some group messaging that it is beneficial for overall health.”

Dr. Ashok Seth, chairman of Fortis Escorts Heart Institute, and Dr. Sujeet Jha, director of endocrinology at Max Saket, also supported the statement by saying, “Health supplements are not classified as drugs in India. They are categorized as food supplements and, therefore, widely advertised. Some of them are endorsed by film stars.”
Dr. Seth further added, “Drug companies are capitalizing on sentiments of patients where their belief is that if they take vitamins, they will feel less tired and physically better.”
Dr Sandeep Mishra, professor of cardiology at AIIMS, India stressed on the need to eat healthier foods rather than consuming health supplements. He said, “There is an urgent need to warn people against over-use of supplements. They can help only if there is a known deficiency of a particular vitamin or mineral. Otherwise, long-term usage of such supplements can be harmful.”
from Drugdu  https://goo.gl/QgQoHk
By Ddu

2018年7月15日星期日

China’s Import and Export Market Report of Vitamins

Vitamins are trace organic substances that humans and animals must obtain from food to maintain normal physiological functions. They play an important role in human growth, metabolism, and development.
They consist of many types and different chemical structures and most of them are components of coenzymes (or prosthetic groups) of certain enzymes and are mainly classified into fat-soluble vitamins (vitamin A, vitamin D, vitamin E, vitamin K) and water-soluble vitamins (B vitamins, vitamin C, etc.)
Today, Ddu, the leading global pharmaceutical & medical device B2B online platform will share China’s Import and Export Market Report of Vitamin with you.

I.  Global situation of the vitamins market
Vitamins have become one of the major bulk products in the international market. At the end of the 20th century, the market value of various vitamin raw materials consumed every year in the pharmaceutical, nutraceutical and other industries around the world, reached 2.5 billion USD. Among the varieties of vitamins, vitamin C, vitamin E, and vitamin A have become the three pillar products in the international vitamin market with total annual sales exceeding 2 billion USD.
In terms of global consumption, Europe, the United States, Asia, and Australia are the major markets. Additionally, vitamin health products in Europe, the United States, and Australia take the lead and occupy important shares. Asia, as the fastest growing economy in the world, is a consumption highlight for the global vitamin market.
At present, the global vitamin industry production pattern has basically formed a three-polar production pattern with China as the production center and Germany’s BASF, and Dutch DSM as complementary ones.
What's more, most varieties have formed oligopolistic competition market patterns, such as VE (vitamin E) and VA (vitamin A) monopolized by DSM, BASF and NHU with a stable competition pattern and over 70% CR4 capacity while there are 6 global vitamin C suppliers. In addition to the factory of DSM in Scotland, the remaining 5 are in China, namely CSPC Pharma, Northeast Pharma, NCPC, Aland and Luwei Pharma.
II.  China’s vitamin market
China is a major producer of vitamins and is one of the very few countries able to produce all vitamin varieties mentioned so far.
According to statistics from China Pharmaceutical Industry Association (CPIA) and Feed Industry Association (CFIA), China's vitamin production in 2017 reached 290,000 tons, which was the same as the previous year, accounting for 70.9% of the world's total output. Because of the dramatic increase in price, the market value rocketed to 3.44 billion USD, an increase of 22.7% over the same period of the previous year.
Vitamin E, vitamin C, and vitamin A are the main products of China's vitamin market. According to statistics from the CPIA and the CFIA, China's vitamin E output accounted for the largest international market share with 95,000 tons in 2016.
Although China joined the market for vitamin E production relatively late, its market is growing rapidly and with increasing efforts in R&D and breakthrough progress in production technology and equipment of natural VE and other areas, China's natural vitamin E's annual output has increased significantly.

III.  China’s import of vitamins
Vitamin A, as one of the three most popular products in China's vitamin market, is increasing in demand.
Given the high technical threshold for the production of vitamin A, currently, only NHU, Zhejiang Medicine and Xiamen Kingdomway have achieved large-scale production. Therefore, the domestic market is in short supply and extra drugs are imported to meet demands.
The following chart shows the trends of China’s import of vitamin A from 2010 to 2016.
Despite the fact that China is a big producer of vitamin C, there is a great imbalance between its production and consumption. Most of the vitamin C produced in China is exported as domestic consumption per capita is far lower than the per capita consumption of 60-90 grams of developed countries in Europe and North America.
Due to the circumstances and steady increase in demand, China is largely dependent on the import of vitamin C. According to Chinese customs’ statistics, China's import of vitamin C from 2016 to January 2018 was as follows:

IV.  China’s export of vitamins
Nowadays, China has become one of the world's largest exporters of vitamins as a result of the country’s production technology and product quality. 
Almost all the vitamins in the domestic market are now produced by wholly-owned or joint ventures in the country, and a large part of them are exported, making China an important vitamin supplier in the international market. According to China customs, the total amount of China's export of vitamins in 2017 was 224,000 tons, a year-on-year increase of 1.3% with an export value amounting to 2.65 billion USD (a year-on-year increase of 22.7%).
Vitamin E and vitamin C accounted for 88% of total exports while the international vitamin C market has been monopolized by China due to advantages in technology and production capacity.
From the perspective of China’s vitamin export structure, the main export countries are the United States, Germany, the Netherlands, Japan, Canada, Thailand, and Brazil.

V.  Leading Chinese companies
a.  Zhejiang NHU Company Ltd.
Reliable and recognized brands of internationally renowned pharmaceuticals and cosmetics company
Representative product: Vitamin E
Indication: Antioxidant, fertility enhancement after hydrolysis, prevention of miscarriage, capillary bleeding and menopausal syndrome etc.
Main exporting regions: Europe, South America, North America, China, Asia Pacific, Middle East

b. Zhejiang Medicine Co., Ltd
The large-scale joint-stock integrated pharmaceutical company, quality supplier, and partner in the international market.
Representative product: Vitamin E
Indication: Antioxidant, fertility enhancement after hydrolysis, prevention of miscarriage, capillary bleeding and menopausal syndrome etc.
Main exporting regions: USA, Tanzania, Pakistan

c.  Yifan Pharmaceutical Co., Ltd
Pharmaceutical innovative R&D and production company and the first Chinese innovative biopharmaceutical enterprise to enter phase II and phase III clinical trials in the United States with more than 90 international and domestic drug-related patents.
Representative product: D-Calcium Pantothenate
Indication: Calcium-D-Pantothenate belongs to vitamin B. It is part of Coenzyme A and is mainly used in medicine, food, and feed.
Main exporting regions: Europe and America

VI.  There are great prospects in the vitamin market
With the improvement of people's living standards and the enhancement of their own health care awareness, the market for vitamin health products is rapidly growing with broad potential. Globally, vitamins are the most important nutritional health products and it's widely acknowledged that they help to maintain human health. According to IMS statistics, in the USA, the market for healthcare products exceeds 8 to10 billion USD, accounting for 15% of the entire healthcare product market.
In addition to the stable markets of developed countries in Europe and the United States, markets in emerging countries such as the Asia-Pacific region are showing rapid growth, and are catching up. The SARS epidemic in China and Southeast Asia in 2003 also resulted in people becoming more health aware.
As the most science-based health products, the vitamin is widely accepted by the public. Vitamin C health products such as vitamin C electuaries, vitamin C and E compound electuaries and multivitamin tablets (which are in short supply) indicating a huge market for vitamin health products in China is on the horizon.

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Do Multivitamins Really Help?

Multivitamins and mineral supplements are consumed to add extra nutritional value to the body and are a multi-million dollar industry. But do they actually add any value to our lives?
This was the question a research team from the St Michael's Hospital and the University of Toronto in Canada was asking when they conducted a study where they found that the most commonly used multivitamins and mineral supplements provide no health benefits but aren’t harmful either. They don’t, however, assist in the prevention of cardiovascular diseases, strokes or premature death.
The study did find that folic acid alone or in combination, may reduce cardiovascular diseases and strokes but niacin and antioxidants showed little effect.
David Jenkins, lead author of the study said, "We were surprised to find so few positive effects of the most common supplements that people consume; our review found that if you want to use multivitamins, vitamin D, calcium or vitamin C, it does no harm - but there is no apparent advantage either."
Jenkins further added, "These findings suggest that people should be conscious of the supplements they're taking and ensure they're applicable to the specific vitamin or mineral deficiencies they have been advised of by their healthcare provider; In the absence of significant positive data - apart from folic acid's potential reduction in the risk of stroke and heart disease - it's most beneficial to rely on a healthy diet to get your fill of vitamins and minerals; so far, no research on supplements has shown us anything better than healthy servings of less processed plant foods including vegetables, fruits, and nuts.”
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from Drugdu  https://goo.gl/QgQoHk